ALLYL-NOR-MORPHINE

Catalytic Stereospecific Allyl–Allyl Cross-Coupling of Internal Allyl Electrophiles with AllylB(pin)

Application of internal electrophiles in catalytic stereospecific allyl-allyl cross-coupling enable the rapid construction of multisubstituted 1,5-dienes, including those with all carbon quaternary centers. Compounds with minimal steric differentiation can be synthesized with high enantiomeric excess.

Catalytic intermolecular allyl-allyl cross-couplings between alcohols and boronates.

We developed catalytic intermolecular C(sp(3))-C(sp(3)) cross-couplings between various allyl alcohols and allyl boronates, which proceeded smoothly in the presence of nickel(0) under mild conditions to form 1,5-dienes with excellent linear- and γ-selectivity; the use of boronates proved to be crucial in terms of reactivity.

The Inhibition of the Liver Microsomal N-demethylation of Morphine by N-allyl Normorphine and Its Pharmacological Implications.

Apoptosis in Drosophila: neither fish nor fowl (nor man, nor worm).

Studies in a wide variety of organisms have produced a general model for the induction of apoptosis in which multiple signaling pathways lead ultimately to activation of the caspase family of proteases. Once activated, these enzymes cleave key cellular substrates to promote the orderly dismantling of dying cells. A broad similarity exists in the cell death pathways operating in different organi...

Allyl 4-hydroxy­phenyl carbonate

The title mol-ecule, C(10)H(10)O(4), is a functionalized carbonate used in the synthetic route to organic glasses. The central CH fragment of the allyl group is disordered over two positions, with occupancies in a 0.758 (10):0.242 (10)ratio. This disorder reflects the torsional flexibility of the oxygen-allyl group, although both disordered parts present the expected anti-clinal conformation, w...